Looking for Morfina substitutes

2002/07/22 Orobengoa, Olatz - Elhuyar Zientziaren Komunikazioa

• Farmakologia

Conical shell snail species (Conus sp.) produce toxins called conotoxins. These substances are used for the paralyzation and capture of small fish. These toxins have the ability to block neuronal communication and, according to scientists, can relieve pain at lower doses.

A
group of scientists from the University of Melbourne have discovered a new substance belonging to the group of conotoxins. He has been called ACV1 and is already in patentability process.

ACV1 blocks acetylcholine nicotinic receptors that work in the transmission of pain in neurons. In this way, it manages to relieve the transmission of painful and tactile sensations.

Scientific
tests with rats have shown that it is 10,000 times more effective than morphine. In addition, it helps to complete the affected neurons and does not create addictions.

This last characteristic makes it very suitable for patients with chronic pain, so it has been considered as a substitute for morphine.

However, the mechanism of the toxin is not yet fully known and further studies are needed to demonstrate that it does not produce any side effects or dependence. Scientists have stated that a long study will be necessary before starting human testing.